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Prednisone tablets 5 mg apo B) or placebo daily. Subjects in both groups took their prescribed vitamin D supplements (400 IU D3 daily, 2.5 mg paricalcitol). All subjects were followed for 12 weeks. Subjects were followed for 12 weeks and compared over a 24-week period (24 weeks total); there were six dabs (days of vitamin D treatment) after the last dose of placebo. For each dabs, there were 1-d placebo dabs (no vitamin D). To assess the effect of a 24-wk vitamin D intervention, the effect of intervention on skin color was Atorvastatin ratiopharm 20 mg preis compared between treatments: the same subjects receiving all-supplemental vitamins D and placebo were followed for 24 weeks at the end of first 24-week treatment period, which they received on the same schedule and at dose as in the second 24-wk treatment period (as in all previous studies). At the end of second 24-wk treatment period, a skin color measurement was obtained at the center of forearm (in absence intervention or placebo dabs) in a subset of 11 subjects (6 those who received placebo) and at the skin center on forearm of the other 10 participants using a standard photoplethysmography technique. Subjects were followed for an average of 24 weeks; during this period, 1-d placebo dabs (no vitamin D) were given at the center (day of last dose the placebo) as a "treatment-free" period. Participants were followed for 12 weeks as above. Skin color measurements at the center of forearm and on the 12 subjects (6 of those who received placebo) were obtained by standard photoplethysmography. (A) The center of forearm was examined with calipers. All measurements were taken in the absence of vitamin D treatment. Statistical methods Subjects were categorized according to vitamin D status (Table 1) and in two groups (high-vitamin D vs. low-vitamin D) on the basis of their baseline values at and on the basis of treatment dose (Table 2). Before entering the trial, subjects and researchers were blinded to treatment; however, the investigators were not blind to the vitamin D group. main hypotheses that were examined to assess the difference between groups in terms of improvement skin color, and to compare differences between groups in terms of skin thickness the finger tips and in terms of sun exposure. We also examined whether there was an interaction effect between vitamin D status and the treatment dose. Data analyses were performed using SPSS v13 for Windows. P values less than or equal to 0.05 were considered indicate statistically significant differences. Table 1. Baseline (days 6 to 12) Intervention Groups (n = 11) High-Vitamin D 6) Low-Vitamin (n = 10) Difference in Variables Improvement %a Mean (SD) % Change Age, y 36.0 (4.7) (5.4) −3.2 1.5 (0.6) 39.4 (6.1) Weight, kg 73.0 (9.1) 83.9 (21.4) −4.8 1.4 (0.9) −24.0 (12.3) BMI, kg/m2 23.8 (3.5) 25.8 −1.7 1.

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